Immune stimulation with PEGylated human IL-10 (AM0010) in patients with pancreatic and colorectal cancer

 

AM0010 is being developed by ARMO BioSciences.

PEGylation of IL-10 allows for an extended half life in the body.

IL-10 is known to induce activation of STAT3 in CD8+ T cells which leads to increased survival, proliferation and cytotoxicity towards cancer. In preclinical studies, PEGylated IL-10 induced CD8+ T cell mediated tumor rejection and synergized with cytotoxic chemotherapies [1].

AM0010 is currently undergoing a phase I clinical trial for patients with advanced solid tumors including pancreatic and colon cancer [2]. Preliminary data suggested that AM0010 enhanced immune stimulation in these “immune resistant” cancers [3].

It is important to note that the mechanism of action of AM0010 relies upon the presence of CD8+ T cells within the tumor. Agents that promote the presence of of these cells are likely to be synergistic with AM0010.

 

Refs

  1. Mumm JB, Emmerich J, Zhang X, Chan I, Wu L, Mauze S, Blaisdell S, Basham B, Dai J, Grein J, Sheppard C, Hong K, Cutler C, Turner S, LaFace D, Kleinschek M, Judo M, Ayanoglu G, Langowski J, Gu D, Paporello B, Murphy E, Sriram V, Naravula  S, Desai B, Medicherla S, Seghezzi W, McClanahan T, Cannon-Carlson S, Beebe AM, Oft M. IL-10 elicits IFNγ-dependent tumor immune surveillance. Cancer Cell. 2011  Dec 13;20(6):781-96. doi: 10.1016/j.ccr.2011.11.003. PubMed PMID: 22172723.
  2. A Phase 1 Study of AM0010 in Patients With Advanced Solid Tumors. NCT02009449.
  3. J Clin Oncol 34, 2016 (suppl; abstr 3082). Poster.

 

 

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