Mul-1867 a new compound with potential as a broad range topical antimicrobial agent

Mul-1867 (poly-N1-hydrazino(imino)-methyl-1,6-hexanediamine) is a member of the polymeric guanidine family developed by TGV-Therapeutics [1]. It lyses the cell membrane of both gram-positive and gram-negative bacteria including antibiotic resistant strains such as MRSA. It is also effective against biofilms making it attractive as a topical agent.

Mul-1867 could have applications in dentistry, otolaryngology, surgery and gynecology as well as preventing hospital acquired infections. It may be that it is suitable for incorporation into medical devices to prevent biofilm development. However all these developments will require clinical testing.


  1. Tetz, George, and Victor Tetz. ‘In Vitro Antimicrobial Activity of a Novel Compound, Mul-1867, against Clinically Important Bacteria’. Antimicrobial Resistance and Infection Control 4, no. 1 (December 2015). doi:10.1186/s13756-015-0088-x.

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